He got his start in stand-up comedy in high school by impersonating his principal and other staff over his high school's PA system.

However, right before the season started, casting changes were made and he was left off the show.

It was said that many of the producers felt he was too similar in humor style to Dana Carvey, who was also joining the show in 1986, and that was why the change was made.

Coulier has done extensive voice work for shows including Extreme Ghostbusters, The Real Ghostbusters, and Slimer!

and the Real Ghostbusters (taking over the character of Peter Venkman after Lorenzo Music's departure from the role), Muppet Babies after Howie Mandel left (Baby Animal, Baby Bunsen, Bean Bunny, and Uncle Statler and Waldorf, even a pre-teen Janice for one episode), Scooby and Scrappy-Doo, The Jetsons, Rude Dog and the Dweebs, and Detention.

In 2006, he appeared on the TV reality show Skating with Celebrities on FOX, where he was paired with Olympic medalist Nancy Kerrigan. Currently, he is a member of Duck's Breath Mystery Theater touring comedy troupe (which he claims is clean comedy but "not quite as creepy" as Full House) as well as host of the series Animal Kidding.

His work on Robot Chicken is probably his most "adult" to date, voicing off-color situations, like Popeye savagely beating Wimpy over a debt.In 2012, he did more flight training in a Cirrus SR20 to "keep current".Coulier is an ice hockey fan and participates in charity events with the Detroit Red Wings.He also founded his own children's entertainment company F3 Entertainment, in 2000.In 2003, Coulier appeared on season three of The Surreal Life.Coulier has also been known to include harmonica playing in his act.