Hydroxyzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent.
The effectiveness of hydroxyzine as an antianxiety agent for long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies.
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This is probably explained by the fact that mitragynine stimulates the delta opioid receptors when used in small quantities, but tends to increasingly stimulate mu opioid receptors when used in larger quantities.
These are the same receptors that are stimulated when using opiate drugs.
There are several types of kratom available, and new strains seem to appear on the market frequently.
However, in reality these are often commercial Thai or Malaysian types, sold under a different name.
Thai: Thai kratom effects are said to be the longest lasting, and most sedating of all kratom strains.
Nowadays commercial available Thai kratom is grown in countries other than Thailand, as it was banned some years ago. Malaysia: Malaysian kratom is reported to be almost identical to kratom originating from Bali.
Maeng Da: (Thai) Maeng Da kratom is translated as ‘pimp grade’ kratom and originates from Thailand. According to users, Maeng Da is less euphoric than other strains, but it’s praised for its energizing effects.
Critics say it’s more jittery than other Premium Thai strains, and argue it doesn’t last as long.
The physician should reassess periodically the usefulness of the drug for the individual patient.
Hydroxyzine, when administered to the pregnant mouse, rat, and rabbit, induced fetal abnormalities in the rat and mouse at doses substantially above the human therapeutic range.
Inert ingredients for the oral suspension formulation are: carboxymethylcellulose sodium; lemon flavor; propylene glycol; sorbic acid; sorbitol solution; water.